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High dose sildenafil citrate as a salvage therapy for severe erectile ... High dose sildenafil citrate as a salvage therapy for severe erectile ...
13/54 (24.1%) responded to sildenafil at a median maximal dose of 200 mg, 4/13 required 150 mg and 9/13 required 200 mg. 41/54 (76%) failed to respond to ...

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Erectile function was quantified using the erectile function domain of the international index of erectile function (iief) before treatment, with sildenafil 100 mg and with maximal dose of sildenafil and a global efficacy question after 4 weeks of treatment. Dosulepin is readily absorbed from the small intestine and is extensively metabolized on first-pass through the liver into its chief active metabolite, northiaden. Ed, 1654 (30) had mixed vasculogenic ed, 954 (17) had cavernosal veno-occlusive dysfunction, 1154 (20) had post radical retropubic prostatectomy ed and 554 (9) had psychogenic ed.

Polypharmacy in psychiatry practice, volume i multiple medication use strategies pharmacodynamics and drug development perspectives in clinical pharmacology andersen j, kristensen as, bang-andersen b, strmgaard k (2009). Dosulepin can potentiate the effects of alcohol and at least one death has been attributed to this combination. It is or has been marketed under a variety of other brand names as well, including altapin, depresym, dopress, dothapax, dothep, idom, prepadine, protiaden, protiadene, thaden, and xerenal.

Dosulepin is marketed throughout the world mainly under the brand name prothiaden. University of north carolina at chapel hill and the united states national institute of mental health tatsumi m, groshan k, blakely rd, richelson e (1997). Australian centre for sexual health, st lukes hospital complex, sydney, australia.

Inchi1sc19h21nsc1-20(2)--8-15(16)-(17)19h3-6,8-12h,7,13-14h2,1-2h3b17-11 tcas should not be used concomitantly or within 14 days of treatment with monoamine oxidase inhibitors due to the risk for (a dangerously low number of white blood cells in the blood leaving one open to potentially life-threatening infections) the symptoms and the treatment of an overdose are largely the same as for the other tcas. The dictionary of drugs chemical data chemical data, structures and bibliographies lancaster sg, gonzalez jp (1989). They have been described as essentially inactive, and are considered unlikely to contribute to either the therapeutic effects or side effects of dosulepin.

Due to the anticholinergic and antihistamine effects of dosulepin anticholinergic and antihistamine medications may have their effects potentiated by dosulepin and hence these combinations are advised against. Fifty four fully evaluated patients with chronic erectile failure (ed) who had previously failed to respond to a home trial of sildenafil (100 mg) with erections suitable for sexual intercourse were studied. In order to minimise the risk of overdose it is advised that patients only receive a limited number of tablets at a time so as to limit their risk of overdosing.

Each man was treated at home with sildenafil at escalating doses of up to 200 mg until either maximal response or intolerable adverse effects occurred. Anticonvulsants may have their efficacy reduced by dosulepin due to its ability to reduce the seizure threshold. After 4 weeks, treatment was regarded as having improved their erections by 37, 46. The objectives of this study were to evaluate the efficacy and tolerability of high dose sildenafil as a salvage therapy for patients refractory to the maximum recommended dose of sildenafil. However, whereas northiaden has potent activity similarly to dosulepin, the two sulfoxide metabolites have dramatically reduced activity.


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Dosulepin, also known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment ...

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    The dictionary of drugs chemical data chemical data, structures and bibliographies lancaster sg, gonzalez jp (1989). Polypharmacy in psychiatry practice, volume i multiple medication use strategies pharmacodynamics and drug development perspectives in clinical pharmacology andersen j, kristensen as, bang-andersen b, strmgaard k (2009). They have been described as essentially inactive, and are considered unlikely to contribute to either the therapeutic effects or side effects of dosulepin. Ed, 1654 (30) had mixed vasculogenic ed, 954 (17) had cavernosal veno-occlusive dysfunction, 1154 (20) had post radical retropubic prostatectomy ed and 554 (9) had psychogenic ed. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.

    However, whereas northiaden has potent activity similarly to dosulepin, the two sulfoxide metabolites have dramatically reduced activity. Unlike the sulfoxide metabolites, northiaden is thought to play an important role in the effects of dosulepin. Each man was treated at home with sildenafil at escalating doses of up to 200 mg until either maximal response or intolerable adverse effects occurred. In order to minimise the risk of overdose it is advised that patients only receive a limited number of tablets at a time so as to limit their risk of overdosing. This suggests that it in fact has low potency for this action, similarly to other tcas.

    Dosulepin is readily absorbed from the small intestine and is extensively metabolized on first-pass through the liver into its chief active metabolite, northiaden. University of north carolina at chapel hill and the united states national institute of mental health tatsumi m, groshan k, blakely rd, richelson e (1997). . Dosulepin can potentiate the effects of alcohol and at least one death has been attributed to this combination. Due to the anticholinergic and antihistamine effects of dosulepin anticholinergic and antihistamine medications may have their effects potentiated by dosulepin and hence these combinations are advised against. It is also advised that patients are not prescribed any medications that are known to increase the risk of toxicity in those receiving dosulepin due to the potential for mixed overdoses. Australian centre for sexual health, st lukes hospital complex, sydney, australia. It is or has been marketed under a variety of other brand names as well, including altapin, depresym, dopress, dothapax, dothep, idom, prepadine, protiaden, protiadene, thaden, and xerenal. Erectile function was quantified using the erectile function domain of the international index of erectile function (iief) before treatment, with sildenafil 100 mg and with maximal dose of sildenafil and a global efficacy question after 4 weeks of treatment. Dosulepin is marketed throughout the world mainly under the brand name prothiaden.

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